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Magic™ Membrane Protein Human GLP1R (Glucagon like peptide 1 receptor) Expressed in Mammalian expression system for Antibody Discovery, Partial (24-145aa) (CAT#: MPX0032K)

Datasheet
This product is a 42 kDa Human GLP1R membrane protein expressed in Mammalian expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GLP1R
  • Protein Length
  • Partial (24-145aa)
  • Protein Class
  • GPCR
  • Molecular Weight
  • 42 kDa
  • TMD
  • 7
  • Sequence
  • RPQGATVSLWETVQKWREYRRQCQRSL
    TEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHV
    YRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLY

Product Description

  • Expression Systems
  • Mammalian expression system
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute in distilled water
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >90% as determined by reducing SDS-PAGE.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Target

  • Target Protein
  • GLP1R
  • Full Name
  • Glucagon like peptide 1 receptor
  • Introduction
  • This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
  • Alternative Names
  • GLP-1; GLP-1R; GLP-1-R; GLP-1 receptor; GLP1 receptor; seven transmembrane helix receptor; GLP1R; Glucagon like peptide 1 receptor

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