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Magic™ Membrane Protein Human GRIN2A (Glutamate ionotropic receptor NMDA type subunit 2A) Full Length (CAT#: MPC0567K) Made to Order

This product is a 165.2 kDa Human GRIN2A membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRIN2A
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 165.2 kDa
  • TMD
  • 3
  • Sequence
  • MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERE
    LRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVF
    GDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGAS
    IQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDM
    QNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTG
    YDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
    TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSF
    TEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCE
    PDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGM
    NVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEV
    VYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFL
    EPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
    IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLA
    AFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY
    MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTI
    GSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGIC
    HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFT
    GVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
    AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQ
    GKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAV
    STESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPR
    YLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSE
    VERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDP
    YQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
    SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDE
    DQMLQETGNPATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPR
    ELDLSRPSRSISLKDRERLLEGNFYGSLFSVPSSKLSGKKSSLFPQGLED
    SKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSY
    LRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSN
    RRVYKKMPSIESDV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • GRIN2A
  • Full Name
  • Glutamate ionotropic receptor NMDA type subunit 2A
  • Introduction
  • This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A; glutamate receptor ionotropic, NMDA 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; glutamate ionotropic receptor NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; GRIN2A; Glutamate ionotropic receptor NMDA type subunit 2A

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