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Magic™ Membrane Protein Human GRPR (Gastrin releasing peptide receptor) Full Length (CAT#: MPC0331K) Made to Order

This product is a 43.1 kDa Human GRPR membrane protein expressed in Baculovirus/Insect expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GRPR
  • Protein Length
  • Full length
  • Protein Class
  • GPCR
  • Molecular Weight
  • 43.1 kDa
  • TMD
  • 7
  • Sequence
  • MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVI
    ILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASR
    YLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQA
    SHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYP
    HSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNI
    HVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
    FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHS
    TGRSTTCMTSLKSTNPSVATFSLINGNICHERYV

Product Description

  • Expression Systems
  • Baculovirus/Insect expression system
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • GRPR
  • Full Name
  • Gastrin releasing peptide receptor
  • Introduction
  • Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
  • Alternative Names
  • BB2; BB2R; gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor; bombesin receptor 2; GRPR; Gastrin releasing peptide receptor

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