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Magic™ Membrane Protein Human GUCY2C (Guanylate cyclase 2C) Expressed in HEK293 for Antibody Discovery, Partial (21-430aa) (CAT#: MPX0210K)

Datasheet
This product is a 47 kDa Human GUCY2C membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GUCY2C
  • Protein Length
  • Partial (21-430aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 47 kDa
  • TMD
  • 1
  • Sequence
  • SFSSQVSQNCHNGSYEISVLMMGNSAFAEP
    LKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTC
    EGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLS
    CDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETE
    DCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCG
    GPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLS
    PGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPK
    FAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTH
    VNKTYPVDMSPTFTWKNSKLPNDITGRGPQ

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • GUCY2C
  • Full Name
  • Guanylate cyclase 2C
  • Introduction
  • This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive).
  • Alternative Names
  • GUCY2C; GC-C; STAR; DIAR6; GUC2C; MECIL; MUCIL; heat-stable enterotoxin receptor; STA receptor; guanylyl cyclase C; intestinal guanylate cyclase; Guanylate cyclase 2C

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