Magic™ Membrane Protein Human HADHB (Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta) Expressed in E.coli with GST tag at the N-terminus for Antibody Discovery, Partial (35-283aa) (CAT#: MPX4382K)

Datasheet

This product is a 53.8kDa Human HADHB membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
HADHB

Protein Length
Partial (35-283aa)

Protein Class
Transferase

Molecular Weight
53.8kDa

Sequence
APAVQTKTKKTLAKPNIRNVVVVDGVRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRP

Product Description

Expression Systems
E.coli

Tag
GST tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
HADHB

Full Name
Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

Introduction
This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative Names
HADHB; ECHB; MTPB; MSTP029; TP-BETA; trifunctional enzyme subunit beta, mitochondrial; 2-enoyl-Coenzyme A (CoA) hydratase, beta subunit; 3-ketoacyl-Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein, beta subunit; acetyl-CoA acyltransferase; beta-ketothiolase; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit; Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

Gene ID
3032

UniProt ID
P55084

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