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Magic™ Membrane Protein Human HAS1 (Hyaluronan synthase 1) Full Length (CAT#: MPC4207K) Made to Order

Datasheet
This product is a made-to-order Human HAS1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HAS1
  • Protein Length
  • Full length
  • Protein Class
  • Transferase
  • TMD
  • 7
  • Sequence
  • MRQQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDR
    YGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALT
    ISAYQEDPAYLRQCLASARALLYPRARLRVLMVVDGNRAEDLYMVDMFRE
    VFADEDPATYVWDGNYHQPWEPAAAGAVGAGAYREVEAEDPGRLAVEALV
    RTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLEL
    VRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFH
    CVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMG
    YATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAW
    MTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAA
    WLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRRKLAANY
    VPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHLAAGAGAYVG
    YWVAMLTLYWVGVRRLCRRRTGGYRVQV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • HAS1
  • Full Name
  • Hyaluronan synthase 1
  • Introduction
  • Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • HAS1; HAS; HA synthase 1; hyaluronate synthase 1; hyaluronic acid synthase 1; Hyaluronan synthase 1

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