Magic™ Membrane Protein Human HLA-DPA1 (Major histocompatibility complex, class II, DP alpha 1) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, Partial (29-222aa) (CAT#: MPX4451K)

Datasheet

This product is a 26.3kDa Human HLA-DPA1 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
HLA-DPA1

Protein Length
Partial (29-222aa)

Protein Class
Immunity

Molecular Weight
26.3kDa

Sequence
AGAIKADHVSTYAAFVQTHRPTGEFMFEFDEDEMFYVDLDKKETVWHLEEFGQAFSFEAQGGLANIAILNNNLNTLIQRSNHTQATNDPPEVTVFPKEPVELGQPNTLICHIDKFFPPVLNVTWLCNGELVTEGVAESLFLPRTDYSFHKFHYLTFVPSAEDFYDCRVEHWGLDQPLLKHWEAQEPIQMPETTE

Product Description

Expression Systems
E.coli

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
HLA-DPA1

Full Name
Major histocompatibility complex, class II, DP alpha 1

Introduction
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Alternative Names
HLA-DPA1; DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1; HLA class II histocompatibility antigen, DP alpha 1 chain; HLA DPA1; HLA-DPA1*01:03:01:New; HLA-DPA1*02:01:01:NEW; HLA-SB alpha chain; MHC class II DP alpha chain; MHC class II DP3-alpha; MHC class II HLA-DPA1 antigen; MHC class II antigen DP alpha chain; MHC class II protein; Major histocompatibility complex, class II, DP alpha 1

Gene ID
3113

UniProt ID
P20036

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