Magic™ Membrane Protein Human HLA-DRB1 (Major histocompatibility complex, class II, DR beta 1) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, Partial (31-266aa) (CAT#: MPX4450K)

Datasheet

This product is a 30.9kDa Human HLA-DRB1 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
HLA-DRB1

Protein Length
Partial (31-266aa)

Protein Class
Immunity

Molecular Weight
30.9kDa

Sequence
DTRPRFLEYSTGECYFFNGTERVRLLERHFHNQEELLRFDSDVGEFRAVTELGRPVAESWNSQKDILEDRRAAVDTYCRHNYGAVESFTVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPRGFLS

Product Description

Expression Systems
E.coli

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
HLA-DRB1

Full Name
Major histocompatibility complex, class II, DR beta 1

Introduction
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene.

Alternative Names
HLA-DRB1; SS1; DRB1; HLA-DRB; HLA-DR1B; major histocompatibility complex, class II, DR beta 1 precursor; HLA class II histocompatibility antigen, DR-1 beta chain; MHC class II HLA-DR beta 1 chain; human leucocyte antigen DRB1; lymphocyte antigen DRB1; Major histocompatibility complex, class II, DR beta 1

Gene ID
3123

UniProt ID
Q95IE3

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