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HLA-G
Magic™ Membrane Protein Human HLA-G (Major histocompatibility complex, class I, G) Expressed in E.coli with 6xHis and SUMO tag at the N-terminus for Antibody Discovery, Partial (25-308aa)

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Magic™ Membrane Protein Human HLA-G (Major histocompatibility complex, class I, G) Expressed in E.coli with 6xHis and SUMO tag at the N-terminus for Antibody Discovery, Partial (25-308aa) (CAT#: MPX4232K)

Datasheet

This product is a 48.7kDa Human HLA-G membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
HLA-G

Protein Length
Partial (25-308aa)

Protein Class
Immunity

Molecular Weight
48.7kDa

TMD
1

Sequence
GSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQSSLPTIPI

Product Description

Expression Systems
E.coli

Tag
6xHis and SUMO tag at the N-terminus

Protein Format
Soluble

Purity
>85% as determined by SDS-PAGE.

Buffer
Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

Target Protein
HLA-G

Full Name
Major histocompatibility complex, class I, G

Introduction
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

Alternative Names
HLA-G; MHC-G; HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; HLA-G histocompatibility antigen, class I, G; MHC class I antigen G; MHC class Ib antigen; b2 microglobulin; mutant MHC class I antigen; mutant MHC class Ib antigen; Major histocompatibility complex, class I, G

Gene ID
3135

UniProt ID
P17693

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