Magic™ Membrane Protein Human IGF2R (Insulin like growth factor 2 receptor) Expressed in NS0 Cells for Antibody Discovery, Partial (1510-2108 aa) (CAT#: MPX4715K)

Datasheet

This product is a Human IGF2R membrane protein expressed in NS0 expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
IGF2R

Protein Length
Partial (1510-2108 aa)

Protein Class
Transporter

Molecular Weight
67 kDa

Sequence
S NEHDDCQVTN PSTGHLFDLS SLSGRAGFTA AYSEKGLVYM SICGENENCP
PGVGACFGQT RISVGKANKR LRYVDQVLQL VYKDGSPCPS KSGLSYKSVI SFVCRPEAGP
TNRPMLISLD KQTCTLFFSW HTPLACEQAT ECSVRNGSSI VDLSPLIHRT GGYEAYDESE
DDASDTNPDF YINICQPLNP MHGVPCPAGA AVCKVPIDGP PIDIGRVAGP PILNPIANEI
YLNFESSTPC LADKHFNYTS LIAFHCKRGV SMGTPKLLRT SECDFVFEWE TPVVCPDEVR
MDGCTLTDEQ LLYSFNLSSL STSTFKVTRD SRTYSVGVCT FAVGPEQGGC KDGGVCLLSG
TKGASFGRLQ SMKLDYRHQD EAVVLSYVNG DRCPPETDDG VPCVFPFIFN GKSYEECIIE
SRAKLWCSTT ADYDRDHEWG FCRHSNSYRT SSIIFKCDED EDIGRPQVFS EVRGCDVTFE
WKTKVVCPPK KLECKFVQKH KTYDLRLLSS LTGSWSLVHN GVSYYINLCQ KIYKGPLGCS
ERASICRRTT TGDVQVLGLV HTQKLGVIGD KVVVTYSKGY PCGGNKTASS VIELTCTKTV
GRPAFKRF

Product Description

Activity
Yes

Expression Systems
NS0

Tag
6xHis tag at C-terminal

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Endotoxin
<1.0 EU per μg by the LAL method

Purity
>90% as determined by SDS-PAGE

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
IGF2R

Full Name
Insulin like growth factor 2 receptor

Introduction
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).

Alternative Names
IGF2R; MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R; cation-independent mannose-6-phosphate receptor; 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; M6P/IGF2 receptor; insulin-like growth factor II receptor; Insulin like growth factor 2 receptor

Gene ID
3482

UniProt ID
P11717

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