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Magic™ Membrane Protein Human ITGA4 (Integrin subunit alpha 4) Full Length (CAT#: MPC1928K) Made to Order

This product is a 114.9 kDa Human ITGA4 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ITGA4
  • Protein Length
  • Full length
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 114.9 kDa
  • TMD
  • 1
  • Sequence
  • MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNT
    LFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQT
    CEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKN
    IFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQA
    GISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSY
    LGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK
    KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAV
    MNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAI
    YIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAV
    GAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTL
    CFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQV
    SSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ
    PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLA
    VGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEV
    TDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATC
    ENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETC
    MVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTG
    ECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF
    LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRV
    IELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMW
    KAGFFKRQYKSILQEENRRDSWSYINSKSNDD

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • ITGA4
  • Full Name
  • Integrin subunit alpha 4
  • Introduction
  • The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • ITGA4; IA4; CD49D; integrin alpha-4; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; integrin alpha-IV; very late activation protein 4 receptor, alpha 4 subunit; Integrin subunit alpha 4

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