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This product is a 117.2 kDa Human ITGA6 membrane protein expressed in HEK293T. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
Product Specifications
Host Species
Human
Target Protein
ITGA6
Protein Length
Full-length
Protein Class
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Anti-DDK affinity column followed by conventional chromatography steps
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Target
Target Protein
ITGA6
Full Name
Integrin subunit alpha 6
Introduction
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.