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This product is a 126.1 kDa Human ITGAL membrane protein expressed in HEK293T. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
Product Specifications
Host Species
Human
Target Protein
ITGAL
Protein Length
Full-length
Protein Class
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Anti-DDK affinity column followed by conventional chromatography steps
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Target
Target Protein
ITGAL
Full Name
Integrin subunit alpha L
Introduction
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.