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Magic™ Membrane Protein Human KCNN3 (Potassium calcium-activated channel subfamily N member 3) Full Length (CAT#: MPC1047K) Made to Order

Datasheet
This product is a 81.3 kDa Human KCNN3 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KCNN3
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 81.3 kDa
  • TMD
  • 6
  • Sequence
  • MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAA
    PQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGL
    LHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPG
    GGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIE
    AETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTA
    SSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVI
    ETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNG
    ADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAE
    ADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFV
    MKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWL
    ISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTK
    AEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKH
    QRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSE
    DLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSV
    AVGTTHTPISDSPIGVSSTSFPTPYTSSSSC

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KCNN3
  • Full Name
  • Potassium calcium-activated channel subfamily N member 3
  • Introduction
  • Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • KCNN3; SK3; ZLS3; hSK3; SKCA3; KCa2.3; small conductance calcium-activated potassium channel protein 3; SKCa 3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; small conductance calcium-activated potassium channel 3; Potassium calcium-activated channel subfamily N member 3

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