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Magic™ Membrane Protein Human KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3) Full Length (CAT#: MPC2449K) Made to Order

Datasheet
This product is a made-to-order Human KDELR3 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KDELR3
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • TMD
  • 7
  • Sequence
  • MNVFRILGDLSHLLAMILLLGKIWRSKCCKGISGKSQILFALVFTTRYLD
    LFTNFISIYNTVMKVVFLLCAYVTVYMIYGKFRKTFDSENDTFRLEFLLV
    PVIGLSFLENYSFTLLEILWTFSIYLESVAILPQLFMISKTGEAETITTH
    YLFFLGLYRALYLANWIRRYQTENFYDQIAVVSGVVQTIFYCDFFYLYVT
    KVLKGKKLSLPMPI

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • KDELR3
  • Full Name
  • KDEL endoplasmic reticulum protein retention receptor 3
  • Introduction
  • This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • KDELR3; ERD2L3; ER lumen protein-retaining receptor 3; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3; KDEL receptor 3; KDEL endoplasmic reticulum protein retention receptor 3

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