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Magic™ Membrane Protein Human KREMEN2 (Kringle containing transmembrane protein 2) Full Length (CAT#: MPC1618K) Made to Order

This product is a 48.8 kDa Human KREMEN2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • KREMEN2
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 48.8 kDa
  • TMD
  • 1
  • Sequence
  • MGTQALQGFLFLLFLPLLQPRGASAGSLHSPGLSECFQVNGADYRGHQNR
    TGPRGAGRPCLFWDQTQQHSYSSASDPHGRWGLGAHNFCRNPDGDVQPWC
    YVAETEEGIYWRYCDIPSCHMPGYLGCFVDSGAPPALSGPSGTSTKLTVQ
    VCLRFCRMKGYQLAGVEAGYACFCGSESDLARGRLAPATDCDQICFGHPG
    QLCGGDGRLGVYEVSVGSCQGNWTAPQGVIYSPDFPDEYGPDRNCSWALG
    PPGAALELTFRLFELADPRDRLELRDAASGSLLRAFDGARPPPSGPLRLG
    TAALLLTFRSDARGHAQGFALTYRGLQDAAEDPEAPEGSAQTPAAPLDGA
    NVSCSPRPGAPPAAIGARVFSTVTAVSVLLLLLLGLLRPLRRRSCLLAPG
    KGPPALGASRGPRRSWAVWYQQPRGVALPCSPGDPQAEGSAAGYRPLSAS
    SQSSLRSLISAL

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • KREMEN2
  • Full Name
  • Kringle containing transmembrane protein 2
  • Introduction
  • This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
  • Alternative Names
  • KREMEN2; KRM2; kremen protein 2; dickkopf receptor 2; kringle domain-containing transmembrane protein 2; kringle-containing protein marking the eye and the nose; Kringle containing transmembrane protein 2

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