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Magic™ Membrane Protein Human LGR5 (Leucine rich repeat containing G protein-coupled receptor 5) Expressed in CHO for Antibody Discovery, Partial (22-560aa) (CAT#: MPX0050K)

Datasheet
This product is a 87 kDa Human LGR5 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • LGR5
  • Protein Length
  • Partial (22-560aa)
  • Protein Class
  • GPCR
  • Molecular Weight
  • 87 kDa
  • TMD
  • 7
  • Sequence
  • GSSPRSGVLLRGCPTHCHCEPDGRMLLRV
    DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGN
    ALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI
    SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHH
    IPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP
    TAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSA
    FQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQ
    LPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSL
    RSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL
    TGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDN
    SSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKP
    CEHLLDGWLI

Product Description

  • Expression Systems
  • CHO
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in PBS.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • LGR5
  • Full Name
  • Leucine rich repeat containing G protein-coupled receptor 5
  • Introduction
  • The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • FEX; HG38; GPR49; GPR67; GRP49; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; orphan G protein-coupled receptor HG38; LGR5; Leucine rich repeat containing G protein-coupled receptor 5

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