Magic™ Membrane Protein Human LILRB5 (Leukocyte immunoglobulin like receptor B5) Expressed in HEK293 for Antibody Discovery, Partial (24-458aa) (CAT#: MPX0388K)

Datasheet

This product is a 74 kDa Human LILRB5 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
LILRB5

Protein Length
Partial (24-458aa)

Protein Class
Receptor; Immunity

Molecular Weight
74 kDa

Sequence
GTLPKPTLWAEPASVIARGKPVTLWCQ
GPLETEEYRLDKEGLPWARKRQNPLEPGAKAKFHIPSTVYDSAGRYRCYY
ETPAGWSEPSDPLELVATGFYAEPTLLALPSPVVASGGNVTLQCDTLDGL
LTFVLVEEEQKLPRTLYSQKLPKGPSQALFPVGPVTPSCRWRFRCYYYYR
KNPQVWSNPSDLLEILVPGVSRKPSLLIPQGSVVARGGSLTLQCRSDVGY
DIFVLYKEGEHDLVQGSGQQPQAGLSQANFTLGPVSRSHGGQYRCYGAHN
LSPRWSAPSDPLDILIAGLIPDIPALSVQPGPKVASGENVTLLCQSWHQI
DTFFLTKEGAAHPPLCLKSKYQSYRHQAEFSMSPVTSAQGGTYRCYSAIR
SYPYLLSSPSYPQELVVSGPSGDPSLSPTGSTPTPGPEDQPLTPTGLDPQ
SGLGRHLG

Product Description

Activity
Yes

Expression Systems
HEK293

Tag
hIgG1 Fc tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 500 μg/mL in PBS.

Endotoxin
<0.10 EU per 1 μg of the protein by the LAL method.

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
LILRB5

Full Name
Leukocyte immunoglobulin like receptor B5

Introduction
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Names
LILRB5; LIR8; CD85C; LIR-8; leukocyte immunoglobulin-like receptor subfamily B member 5; CD85 antigen-like family member C; leucocyte Ig-like receptor B5; leukocyte immunoglobulin-like receptor 8; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5; Leukocyte immunoglobulin like receptor B5

Gene ID
10990

UniProt ID
O75023

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