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Magic™ Membrane Protein Human MADCAM1 (Mucosal vascular addressin cell adhesion molecule 1) Expressed in NS0 for Antibody Discovery, Partial (1-333aa) (CAT#: MPX0774K)

Datasheet
This product is a 59.3 kDa Human MADCAM1 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • MADCAM1
  • Protein Length
  • Partial (1-333aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 59.3 kDa
  • TMD
  • 1
  • Sequence
  • MDFGLALLLAGLLGLLLGQSLQVKPLQVEPPEPVVAVALGASRQLTCRLACADRGASVQW
    RGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVGSCGGRTFQHTVQLLVYAFPDQLTV
    SPAALVPGDPEVACTAHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEEPQGDED
    VLFRVTERWRLPPLGTPVPPALYCQATMRLPGLELSHRQAIPVLHSPTSPEPPDTTSPES
    PDTTSPESPDTTSQEPPDTTSQEPPDTTSQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRS
    PGSTRTRRPEISQAGHTQGKVIPTGSSKPAGDQ

Product Description

  • Activity
  • Yes
  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 200 μg/mL in PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • MADCAM1
  • Full Name
  • Mucosal vascular addressin cell adhesion molecule 1
  • Introduction
  • The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
  • Alternative Names
  • MADCAM1; MACAM1; mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; Mucosal vascular addressin cell adhesion molecule 1

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