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Magic™ Membrane Protein Human MBTPS1 (Membrane bound transcription factor peptidase, site 1) Expressed in E.coli with 6xHis and SUMO tag at the N-terminus for Antibody Discovery, Partial (218-414aa) (CAT#: MPX4639K)

Datasheet
This product is a 37.5kDa Human MBTPS1 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • MBTPS1
  • Protein Length
  • Partial (218-414aa)
  • Protein Class
  • Protease
  • Molecular Weight
  • 37.5kDa
  • TMD
  • 1
  • Sequence
  • DTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTS

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • 6xHis and SUMO tag at the N-terminus
  • Protein Format
  • Soluble
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Tris-based buffer, 50% glycerol

Target

  • Target Protein
  • MBTPS1
  • Full Name
  • Membrane bound transcription factor peptidase, site 1
  • Introduction
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.
  • Alternative Names
  • MBTPS1; S1P; PCSK8; SEDKF; SKI-1; membrane-bound transcription factor site-1 protease; endopeptidase S1P; proprotein convertase subtilisin/kexin type 8; site-1 protease; subtilisin/kexin isozyme-1; Membrane bound transcription factor peptidase, site 1

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