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Magic™ Membrane Protein Human MME (Membrane metalloendopeptidase) Expressed in CHO for Antibody Discovery, Partial (52-750aa) (CAT#: MPX0183K)

Datasheet
This product is a 81 kDa Human MME membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • MME
  • Protein Length
  • Partial (52-750aa)
  • Protein Class
  • Protease
  • Molecular Weight
  • 81 kDa
  • TMD
  • 1
  • Sequence
  • YDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPET
    SSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAID
    SRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVL
    INLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMI
    SVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
    NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPE
    YLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYG
    TTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREV
    FIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLEL
    NYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGR
    NQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
    GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIA
    DNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRP
    EYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW

Product Description

  • Expression Systems
  • CHO
  • Tag
  • 6xHis tag at the N-terminus
  • Protein Format
  • Soluble
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Supplied as a 0.2 μm filtered solution in Tris, NaCl and ZnCl2.

Target

  • Target Protein
  • MME
  • Full Name
  • Membrane metalloendopeptidase
  • Introduction
  • The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
  • Alternative Names
  • MME; NEP; SFE; CD10; CALLA; CMT2T; SCA43; neprilysin; atriopeptidase; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; neprilysin-390; neprilysin-411; neutral endopeptidase 24.11; skin fibroblast elastase; Membrane metalloendopeptidase

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