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Magic™ Membrane Protein Human MSLN (Mesothelin, transcript variant 1) for Antibody Discovery (CAT#: MP1220J)

This product is a 32.9 kDa Human MSLN membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • MSLN
  • Protein Length
  • Partial
  • Protein Class
  • Druggable Genome, Secreted Protein, Transmembrane
  • Molecular Weight
  • 32.9 kDa
  • Sequence
  • EVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELY
    PQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVK
    GRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKA
    RLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQ
    KLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQG

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • C-His
  • Endotoxin
  • Less than 0.01 ng per µg protein as determined by the LAL method
  • Purity
  • >95%, as determined by Coomassie stained SDS-PAGE
  • Buffer
  • 1 x PBS, pH7.2

Target

  • Target Protein
  • MSLN
  • Full Name
  • Mesothelin
  • Introduction
  • This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
  • Alternative Names
  • MPF; SMRP

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