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Magic™ Membrane Protein Human NPR2 (Natriuretic peptide receptor 2) Expressed in NS0 for Antibody Discovery, Partial (23-458aa) (CAT#: MPX0333K)

Datasheet
This product is a 49 kDa Human NPR2 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NPR2
  • Protein Length
  • Partial (23-458aa)
  • Protein Class
  • Receptor
  • Molecular Weight
  • 49 kDa
  • TMD
  • 1
  • Sequence
  • RNLTLAVVLPEHNLSYAWAWPRVGPAVA
    LAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPG
    CVYPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLG
    EFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQH
    QVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDY
    VFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE
    PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNE
    TIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDL
    DSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDK
    TPLSTLAI

Product Description

  • Expression Systems
  • NS0
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 250 μg/mL in PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • NPR2
  • Full Name
  • Natriuretic peptide receptor 2
  • Introduction
  • This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
  • Alternative Names
  • NPR2; GCB; AMDM; ANPb; ECDM; GC-B; NPRB; SNSK; ANPRB; GUC2B; NPRBi; GUCY2B; atrial natriuretic peptide receptor 2; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B; guanylate cyclase 2B; guanylate cyclase B; guanylyl cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); Natriuretic peptide receptor 2

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