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This product is a 68.9 kDa Human NTSR2 membrane protein expressed in in vitro wheat germ expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
Enzyme-linked Immunoabsorbent Assay, Western Blot (Recombinant protein), Antibody Production, Protein Array
Expression Systems
in vitro wheat germ expression system
Tag
GST-tag at N-terminal
Purification
Glutathione Sepharose 4 Fast Flow
Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer
Target
Target Protein
NTSR2
Full Name
Neurotensin receptor 2
Introduction
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
Alternative Names
NTR2; neurotensin receptor type 2; NT-R-2; levocabastine-sensitive neurotensin receptor; neurotensin receptor, type 2