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Magic™ Membrane Protein Human OTOP1 (Otopetrin 1) Full Length (CAT#: MPC0677K) Made to Order

This product is a 67.3 kDa Human OTOP1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • OTOP1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 67.3 kDa
  • TMD
  • 12
  • Sequence
  • MLEGLGSPASPRAAASASVAGSSGPAACSPPSSSAPRSPESPAPRRGGVR
    ASVPQKLAEMLSSQYGLIVFVAGLLLLLAWAVHAAGVSKSDLLCFLTALM
    LLQLLWMLWYVGRSSAHRRLFRLKDTHAGAGWLRGSITLFAVITVILGCL
    KIGYFIGFSECLSATEGVFPVTHSVHTLLQVYFLWGHAKDIIQSFKTLER
    FGVIHSVFTNLLLWANGVLNESKHQLNEHKERLITLGFGNITTVLDDHTP
    QCNCTPPTLCTAISHGIYYLYPFNIEYQILASTMLYVLWKNIGRKVDSHQ
    HQKMQFKSDGVMVGAVLGLTVLAATIAVVVVYLIHIGRSKTKSESALIMF
    YLYAITLLMLMGAAGLAGIRIYRIDEKSLDESKNPARKLDSDLLVGTASG
    SWLISWGSILAILCAEGHPRYTWYNLPYSILAIVEKYIQNLFIFESIHRE
    PEKLSEDIQTLRVVTVCNGNTMPLASSCPKSGGVARDVAPQGKDMPPAAN
    GNVCMRESHDKEEEKQEESSWGGSPSPVRLPRFLQGNAKRKVLRNIAAFL
    FLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMH
    AAASLFEVYCKI

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • OTOP1
  • Full Name
  • Otopetrin 1
  • Introduction
  • This gene encodes a transmembrane protein which belongs to the otopetrin domain protein family and is required for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals that are required for the detection of linear acceleration and gravity. This gene modulates purinergic control of intracellular calcium in vestibular supporting cells. Naturally occurring mutations in the orthologous mouse gene are associated with nonsyndromic otoconia agenesis and a consequent balance defect. The orthologous mouse gene is also induced in white adipose tissue during obesity. The encoded protein is a component of a counterinflammatory pathway that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity.
  • Alternative Names
  • Proton channel OTOP1; OTOP1; Otopetrin 1

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