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This product is a 79.53 kDa Human PDZD3 membrane protein expressed in in vitro wheat germ expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
Enzyme-linked Immunoabsorbent Assay, Western Blot (Recombinant protein), Antibody Production, Protein Array
Expression Systems
in vitro wheat germ expression system
Tag
GST-tag at N-terminal
Purification
Glutathione Sepharose 4 Fast Flow
Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer
Target
Target Protein
PDZD3
Full Name
PDZ domain containing 3
Introduction
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation.
Alternative Names
IKEPP; PDZK2; NHERF4; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; NHERF-4; PDZ domain containing 2; PDZ domain-containing protein 2; PDZ domain-containing protein 2; intestinal and kidney enriched PDZ protein; na/Pi cotransporter C-terminal-associated protein 2; naPi-Cap2; natrium-phosphate cotransporter IIa C-terminal-associated protein 2; natrium-phosphate cotransporter IIa C-terminal-associated protein 2