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Magic™ Membrane Protein Human PPARG (Peroxisome proliferator activated receptor gamma) (CAT#: MP0038F)

MT1 is a class A GPCR that modulates neuronal firing, arterial vasoconstriction, cell proliferation in cancer cells, and reproductive and metabolic functions.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • PPARG
  • Protein Length
  • Full-length
  • Protein Class
  • GPCR Class A
  • Molecular Weight
  • 44.8kDa
  • TMD
  • 7
  • Sequence
  • MASAWSHPQFEKGGGSGGGSGGSAWSHPQFEKGAHHHHHHHHHHENLYFQGQGNGSALPNAS
    QPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPY
    PLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLL
    IWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQR
    VKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNS
    CLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

Product Description

  • Activity
  • Confirmed by radiobinding assay and activation of Gi
  • Expression Systems
  • Sf9
  • Tag
  • Strepx2/His (both N-terminal)
  • Purification
  • Metal Affinity Chromatography in presence of Sarkosyl/CHS
  • Purity
  • >90%
  • Buffer
  • 25mM Na2HPO4 pH 8.0, 150mM NaCl, 0.86%/0.18% Sarkosyl/CHS

Target

  • Target Protein
  • PPARG
  • Full Name
  • Peroxisome proliferator activated receptor gamma
  • Introduction
  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
  • Alternative Names
  • GLM1, CIMT1, NR1C3, PPARG1, PPARG2, PPARG5, PPARgamma

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