Magic™ Membrane Protein Human PTPRJ (Protein tyrosine phosphatase receptor type J) Expressed in E.coli for Antibody Discovery, Partial (997-1337aa) (CAT#: MPX0399K)

Datasheet

This product is a 40 kDa Human PTPRJ membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
PTPRJ

Protein Length
Partial (997-1337aa)

Protein Class
Protein phosphatase

Molecular Weight
40 kDa

Sequence
RKKR
KDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKL
VGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYM
PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCE
EYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF
TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFI
AIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR
SQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA

Product Description

Activity
Yes

Expression Systems
E.coli

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Endotoxin
<1.0 EU per 1 μg of the protein by the LAL method.

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

Buffer
Supplied as a 0.2 μm filtered solution in Tris, NaCl, Glycerol and Betamercaptoethanol.

Target

Target Protein
PTPRJ

Full Name
Protein tyrosine phosphatase receptor type J

Introduction
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative Names
PTPRJ; DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA; receptor-type tyrosine-protein phosphatase eta; CD148 antigen; DEP-1; HPTP eta; R-PTP-J; density-enhanced phosphatase 1; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of; Protein tyrosine phosphatase receptor type J

Gene ID
5795

UniProt ID
Q12913

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