Magic™ Membrane Protein Human RXFP1 (Relaxin family peptide receptor 1) (CAT#: MP0031F)

Datasheet

The relaxin/insulin-like family peptide receptor 1 is the cognate receptor for human relaxin-2 in humans. Human RXFP1 also known as LGR7 is located on chromosome 4q32.1 and is known to activate Erk1/2, tyrosine kinase(s), gene transcription, and nitric oxide (NO) signaling and can also interact with the glucocorticoid receptor (GC).
hRXFP1 is found in a wide range of reproductive tissues including ovary, uterus, placenta, mammary gland, prostate, and testis. The receptor is also present in the heart, kidney, lung, liver and blood cells as well as in a number of areas of the brain such as cortex, organum vasculosum of the lamina terminalis (OVLT), and subfornical organ (SFO). RXFP1 binds peptide hormones consequently relaxin not only has autocrine and paracrine roles but also acts as a neuropeptide. It's a potent chronotropic with inotropic effects on the human heart. Relaxin peptide (RLN) has shown therapeutic effects in an acute heart failure clinical trial.

Product Specifications

Host Species
Human

Target Protein
RXFP1

Protein Length
Full Length

Protein Class
GPCR Class A

Molecular Weight
86.9 kDa

Sequence
MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADED
NCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRA
VPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLY
LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK
PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL
DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQ
RMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTC
FGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWM
ESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGF
IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG
SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGT
ITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWV
EMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS

Product Description

Activity
Validated by SPRi

Application
Screening & display technologies, Structural biology, Antibody development

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>70% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
RXFP1

Full Name
Relaxin family peptide receptor 1

Introduction
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative Names
LGR7, RXFPR1

Gene ID
59350

UniProt ID
Q9HBX9

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