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Magic™ Membrane Protein Human SCN8A (Sodium voltage-gated channel alpha subunit 8) Full Length (CAT#: MPC0709K) Made to Order

This product is a 225.2 kDa Human SCN8A membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SCN8A
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 225.2 kDa
  • TMD
  • 24
  • Sequence
  • MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDED
    SKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRG
    KTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMT
    FSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFS
    VIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK
    LSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGF
    DWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGY
    TSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSF
    YLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAA
    MATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQ
    KELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSI
    PGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDS
    LFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVS
    LIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSI
    MSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIV
    MDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEM
    FLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLR
    VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS
    YKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQ
    AMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQIS
    VIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTG
    ADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAV
    GESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQ
    PEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWF
    ETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLK
    WTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRA
    LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA
    GKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVG
    AGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIF
    GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP
    QKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQM
    ENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGM
    FLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA
    LFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQ
    ITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYI
    IISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDAT
    QFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFA
    FTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAV
    VLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSV
    TKPEKEKQQRAEEGRRERAKRQKEVRESKC

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SCN8A
  • Full Name
  • Sodium voltage-gated channel alpha subunit 8
  • Introduction
  • This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • MED; PN4; CIAT; BFIS5; DEE13; NaCh6; CERIII; EIEE13; MYOCL2; Nav1.6; sodium channel protein type 8 subunit alpha; hNa6/Scn8a voltage-gated sodium channel; sodium channel, voltage gated, type VIII, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.6; voltage-gated sodium channel type VIII alpha protein; SCN8A; Sodium voltage-gated channel alpha subunit 8

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