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Magic™ Membrane Protein Human SELPLG (Selectin P ligand) Expressed in CHO for Antibody Discovery, Partial (42-295aa) (CAT#: MPX0536K)

Datasheet
This product is a 52.6 kDa Human SELPLG membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SELPLG
  • Protein Length
  • Partial (42-295aa)
  • Protein Class
  • Cell adhesion
  • Molecular Weight
  • 52.6 kDa
  • TMD
  • 1
  • Sequence
  • QATEYEYLD
    YDFLPETEPPEMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVT
    ELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTEAQTTPLAATE
    AQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAME
    AQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATE
    AQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKG

Product Description

  • Activity
  • Yes
  • Expression Systems
  • CHO
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.10 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in Tris and NaCl.

Target

  • Target Protein
  • SELPLG
  • Full Name
  • Selectin P ligand
  • Introduction
  • This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • SELPLG; CLA; CD162; PSGL1; PSGL-1; P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen; Selectin P ligand

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