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Magic™ Membrane Protein Human SLC12A1 (Solute carrier family 12 member 1) Full Length (CAT#: MPC0722K) Made to Order

This product is a 121.4 kDa Human SLC12A1 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SLC12A1
  • Protein Length
  • Full length
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 121.4 kDa
  • TMD
  • 12
  • Sequence
  • MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSF
    GDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQT
    FGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSAD
    RVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRL
    SWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISR
    SLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTND
    IRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSN
    NEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANI
    SGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTII
    SGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGI
    FSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYIL
    TFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPA
    YGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVN
    WGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDI
    THAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAA
    VAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGII
    HDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNEC
    EEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEAST
    QFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKIN
    RIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRL
    HESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAA
    NLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • SLC12A1
  • Full Name
  • Solute carrier family 12 member 1
  • Introduction
  • This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
  • Alternative Names
  • BSC1; NKCC2; solute carrier family 12 member 1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; kidney-specific Na-K-Cl symporter; solute carrier family 12 (sodium/potassium/chloride transporter), member 1; solute carrier family 12 (sodium/potassium/chloride transporters), member 1; SLC12A1; Solute carrier family 12 member 1

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