Magic™ Membrane Protein Human SLC22A17 (Solute carrier family 22 member 17) without tag for Antibody Discovery (CAT#: MP1167X)

Datasheet

This product is a 59.2 kDa Human SLC22A17 membrane protein expressed in In vitro wheat germ expression system with proprietary liposome technology. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
SLC22A17

Protein Length
Full-length

Molecular Weight
59.2 kDa

Sequence
MASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL

Product Description

Application
Antibody Production

Expression Systems
In vitro wheat germ expression system with proprietary liposome technology

Purification
None

Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0

Target

Target Protein
SLC22A17

Full Name
Solute carrier family 22 member 17

Introduction
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

Alternative Names
BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3; solute carrier family 22 member 17; 24p3 receptor; NGAL receptor; brain-type organic cation transporter; lipocalin-2 receptor; neutrophil gelatinase-associated lipocalin receptor; potent brain type organic ion transporter; solute carrier family 22 (organic cation transporter), member 17

Gene ID
51310

UniProt ID
Q8WUG5

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