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Magic™ Membrane Protein Human SPPL2B (Signal peptide peptidase like 2B) Full Length (CAT#: MPC2454K) Made to Order

This product is a made-to-order Human SPPL2B membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SPPL2B
  • Protein Length
  • Full length
  • Protein Class
  • Protease
  • TMD
  • 9
  • Sequence
  • MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNP
    QWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTF
    YEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLD
    IFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKK
    RYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYV
    VIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLL
    ALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTL
    LLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVP
    RLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACT
    IAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWT
    GSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQS
    PKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • SPPL2B
  • Full Name
  • Signal peptide peptidase like 2B
  • Introduction
  • This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • SPPL2B; IMP4; PSH4; PSL1; IMP-4; signal peptide peptidase-like 2B; SPP-like 2B; intramembrane protease 4; presenilin homologous protein 4; presenilin-like protein 1; Signal peptide peptidase like 2B

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