Magic™ Membrane Protein Human SREBF1 (Sterol regulatory element binding transcription factor 1) Expressed in vitro E.coli expression system for Antibody Discovery, Partial (1-490aa) (CAT#: MPX0847K)

Datasheet

This product is a 54.5kDa Human SREBF1 membrane protein expressed in vitro E.coli expression system. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
SREBF1

Protein Length
Partial (1-490aa)

Protein Class
Receptor

Molecular Weight
54.5kDa

Sequence
MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPPYAGSGAGGTDPASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGPGIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGNTQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLLQPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTEVEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSRGMLDRSRLAL

Product Description

Expression Systems
in vitro E.coli expression system

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE.

Buffer
Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

Target Protein
SREBF1

Full Name
Sterol regulatory element binding transcription factor 1

Introduction
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively.

Alternative Names
SREBF1; HMD; IFAP2; SREBP1; bHLHd1; sterol regulatory element-binding protein 1; class D basic helix-loop-helix protein 1; Sterol regulatory element binding transcription factor 1

Gene ID
6720

UniProt ID
P36956

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