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Magic™ Membrane Protein Human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1) Expressed in CHO for Antibody Discovery, Partial (49-356aa) (CAT#: MPX0728K)

This product is a 36 kDa Human ST8SIA1 membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ST8SIA1
  • Protein Length
  • Partial (49-356aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 36 kDa
  • TMD
  • 1
  • Sequence
  • YR
    LPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSP
    MGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKS
    GCGRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLL
    WSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLSDVGANQTVLF
    ANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSV
    NMHEQPISHHYYDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQLDPCEDT
    SLQPTS

Product Description

  • Activity
  • Yes
  • Expression Systems
  • CHO
  • Tag
  • 6xHis tag at the C-terminus
  • Protein Format
  • Soluble
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane.
  • Buffer
  • Supplied as a 0.2 μm filtered solution in Tris and NaCl.

Target

  • Target Protein
  • ST8SIA1
  • Full Name
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Introduction
  • Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene.
  • Alternative Names
  • ST8SIA1; GD3S; SIAT8; SIAT8A; SIAT8-A; ST8SiaI; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1; alpha-2,8-sialyltransferase 8A; disialoganglioside (GD3) synthase; ganglioside GD3 synthase; ganglioside GT3 synthase; ganglioside-specific alpha-2,8-polysialyltransferase; sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) A; sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase); sialyltransferase St8Sia I; sialytransferase St8Sia I; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

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