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This product is a 56 kDa Human STEAP2 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alternative Names
STMP; IPCA1; PUMPCn; STAMP1; PCANAP1; metalloreductase STEAP2; STEAP family member 2, metalloreductase; SixTransMembrane Protein of Prostate 1; prostate cancer-associated protein 1; protein up-regulated in metastatic prostate cancer; protein upregulated in metastatic prostate cancer; six transmembrane epithelial antigen of the prostate 2; six-transmembrane epithelial antigen of prostate 2; STEAP2; STEAP2 metalloreductase