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Magic™ Membrane Protein Human TNF (Tumor necrosis factor) for Antibody Discovery (CAT#: MP1199J)

Datasheet
This product is a 17.4 kDa Human TNF membrane protein expressed in E. coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TNF
  • Protein Length
  • Full-length
  • Protein Class
  • Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
  • Molecular Weight
  • 17.4 kDa
  • TMD
  • 1
  • Sequence
  • VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

Product Description

  • Expression Systems
  • E. coli
  • Tag
  • Tag Free
  • Endotoxin
  • < 1 EU/µg
  • Purity
  • >95% as determined by SDS-PAGE and Coomassie blue staining
  • Buffer
  • 20mM phosphate buffer,100mM NaCl, pH 7.2

Target

  • Target Protein
  • TNF
  • Full Name
  • Tumor necrosis factor
  • Introduction
  • This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
  • Alternative Names
  • DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha

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