Magic™ Membrane Protein Human TNFRSF11A (TNF receptor superfamily member 11a) Expressed in NS0 for Antibody Discovery, Partial (29-213aa) (CAT#: MPX0457K)

Datasheet

This product is a 48 kDa Human TNFRSF11A membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
TNFRSF11A

Protein Length
Partial (29-213aa)

Protein Class
Receptor

Molecular Weight
48 kDa

Sequence
QIAPPCTSEKHYEHLGRCCNKC
EPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVA
VVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTV
CKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPA
RKPPNEPHVYLPG

Product Description

Activity
Yes

Expression Systems
NS0

Tag
hIgG1 Fc and 6xHis tag at the C-terminus

Protein Format
Soluble

Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.

Endotoxin
<0.01 EU per 1 μg of the protein by the LAL method.

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.

Target

Target Protein
TNFRSF11A

Full Name
TNF receptor superfamily member 11a

Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Alternative Names
TNFRSF11A; FEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1; TRANCE-R; tumor necrosis factor receptor superfamily member 11A; Paget disease of bone 2; TRANCE recepto;
familial expansile osteolysis; loss of heterozygosity, 18, chromosomal region 1; osteoclast differentiation factor receptor; receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; tumor necrosis factor receptor superfamily, member 11a, NFKB activator; TNF receptor superfamily member 11a

Gene ID
8792

UniProt ID
Q9Y6Q6

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