Magic™ Membrane Protein Human TNFSF10 (TNF superfamily member 10) Expressed in E.coli with 6xHis tag at the N-terminus for Antibody Discovery, Partial (39-281aa) (CAT#: MPX4518K)

Datasheet

This product is a 32.4kDa Human TNFSF10 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
TNFSF10

Protein Length
Partial (39-281aa)

Protein Class
Receptor

Molecular Weight
32.4kDa

Sequence
TNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

Product Description

Expression Systems
E.coli

Tag
6xHis tag at the N-terminus

Protein Format
Soluble

Purity
>90% as determined by SDS-PAGE

Buffer
Tris-based buffer, 50% glycerol

Target

Target Protein
TNFSF10

Full Name
TNF superfamily member 10

Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative Names
TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A; tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor superfamily member 10; TNF superfamily member 10

Gene ID
8743

UniProt ID
P50591

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