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This product is a 52.8 kDa Human ULBP2 membrane protein expressed in In vitro wheat germ expression system with proprietary liposome technology. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.
Enzyme-linked Immunoabsorbent Assay, Western Blot (Recombinant protein), Antibody Production, Protein Array
Expression Systems
In vitro wheat germ expression system with proprietary liposome technology
Tag
GST-tag at N-terminal
Purification
Glutathione Sepharose 4 Fast Flow
Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0
Target
Target Protein
ULBP2
Full Name
UL16 binding protein 2
Introduction
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6.
Alternative Names
N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha; UL16-binding protein 2; NKG2D ligand 2; retinoic acid early transcript 1H; retinoic acid early transcript 1L