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Magic™ Membrane Protein Human UNC80 (Unc-80 homolog, NALCN channel complex subunit) Full Length (CAT#: MPC1039K) Made to Order

This product is a 363.3 kDa Human UNC80 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • UNC80
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 363.3 kDa
  • TMD
  • 4
  • Sequence
  • MVKRKSSEGQEQDGGRGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFE
    RVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSNRNKLG
    HQDKLGVAETKLLHTLHWMLLEAPQDCNNERFGGTDRGSSWGGSSSAFIH
    QVENQGSPGQPCQSSSNDEEENNRRKIFQNSMATVELFVFLFAPLVHRIK
    ESDLTFRLASGLVIWQPMWEHRQPGVSGFTALVKPIRNIITAKRSSPINS
    QSRTCESPNQDARHLEGLQVVCETFQSDSISPKATISGCHRGNSFDGSLS
    SQTSQERGPSHSRASLVIPPCQRSRYATYFDVAVLRCLLQPHWSEEGTQW
    SLMYYLQRLRHMLEEKPEKPPEPDIPLLPRPRSSSMVAAAPSLVNTHKTQ
    DLTMKCNEEEKSLSSEAFSKVSLTNLRRSAVPDLSSDLGMNIFKKFKSRK
    EDRERKGSIPFHHTGKRRPRRMGVPFLLHEDHLDVSPTRSTFSFGSFSGL
    GEDRRGIEKGGWQTTILGKLTRRGSSDAATEMESLSARHSHSHHTLVSDL
    PDPSNSHGENTVKEVRSQISTITVATFNTTLASFNVGYADFFNEHMRKLC
    NQVPIPEMPHEPLACANLPRSLTDSCINYSYLEDTEHIDGTNNFVHKNGM
    LDLSVVLKAVYLVLNHDISSRICDVALNIVECLLQLGVVPCVEKNRKKSE
    NKENETLEKRPSEGAFQFKGVSGSSTCGFGGPAVSGAGDGGGEEGGGGDG
    GGGGGDGGGGGGGGGGPYEKNDKNQEKDESTPVSNHRLALTMLIKIVKSL
    GCAYGCGEGHRGLSGDRLRHQVFRENAQNCLTKLYKLDKMQFRQTMRDYV
    NKDSLNNVVDFLHALLGFCMEPVTDNKAGFGNNFTTVDNKSTAQNVEGII
    VSAMFKSLITRCASTTHELHSPENLGLYCDIRQLVQFIKEAHGNVFRRVA
    LSALLDSAEKLAPGKKVEENEQESKPAGSKRSEAGSIVDKGQVSSAPEEC
    RSFMSGRPSQTPEHDEQMQGANLGRKDFWRKMFKSQSAASDTSSQSEQDT
    SECTTAHSGTTSDRRARSRSRRISLRKKLKLPIGKRNWLKRSSLSGLADG
    VEDLLDISSVDRLSFIRQSSKVKFTSAVKLSEGGPGSGMENGRDEEENFF
    KRLGCHSFDDHLSPNQDGGKSKNVVNLGAIRQGMKRFQFLLNCCEPGTIP
    DASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNITK
    KGLSRGRSPIVGNKRNQKLQWNAAKLFYQWGDAIGVRLNELCHGESESPA
    NLLGLIYDEETKRRLRKEDEEEDFLDDSTVNPSKCGCPFALKMAACQLLL
    EITTFLRETFSCLPRPRTEPLVDLESCRLRLDPELDRHRYERKISFAGVL
    DENEDSKDSLHSSSHTLKSDAGVEEKKEGSPWSASEPSIEPEGMSNAGAE
    ENYHRNMSWLHVMILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIK
    LLYGDSVDSLRESSNISSVALRGKKQKECSDKSCLRTPSLKKRVSDANLE
    GKKDSGMLKYIRLQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLL
    SMDEHMAGAAAAMFLLCAVKVPEAVSDMLMSEFHHPETVQRLNAVLKFHT
    LWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWVP
    QCSGSVQDPINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREA
    SLITAIPITQEACYEPTCTPNSEPEEEVEEVTNLASRRLSVSPSCTSSTS
    HRNYSFRRGSVWSVRSAVSAEDEEHTTEHTPNHHVPQPPQAVFPACICAA
    VLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTIS
    NRQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDA
    ISATLTFLWEVVGYVEGLFFKDLKQTMKKEQCEVKLLVTASMPGTKTLVV
    HGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNL
    IHYNKTYVRDIYPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGR
    VLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAEFSLFSDPQA
    GKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILH
    PEDSALLRQYAATVINTAVHFNHLFSLSGYQWILPTMLQVYSDYESNPQL
    RQAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANNGPSKGVSAQCL
    FDLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLC
    VTVVAYAPESFRSLQMLMVLEALVPCYLQKLKRQTSQVETVPAAREEIAA
    TAALATSLQALLYSVEVLTRPMTAPQMSRCDQGHKGTTTANHTMSSGVNT
    RYQEQGAKLHFIRENLHLLEEGQGIPREELDERIAREEFRRPRESLLNIC
    TEFYKHCGPRLKILQNLAGEPRVIALELLDVKSHMRLAEIAHSLLKLAPY
    DTQTMESRGLRRYIMEMLPITDWTAEAVRPALILILKRLDRMFNKIHKMP
    TLRRQVEWEPASNLIEGVCLTLQRQPIISFLPHLRSLINVCVNLVMGVVG
    PSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVISP
    FTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLP
    PRIISTSRSKNFMLESSPAHCSTPGDAGKDLRREGLAESTSQAAYLALKV
    ILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVL
    LRPFIQCKLLAQPAENHEELSARQHIADQLERRFIPRPLCKSSLIAEFNS
    ELKILKEAVHSGSAYQGKTSISTVGTSTSAYRLSLATMSRSNTGTGTVWE
    QDSEPSQQASQDTLSRTDEEDEENDSISMPSVVSEQEAYLLSAIGRRRFS
    SHVSSMSVPQAEVGMLPSQSEPNVLDDSQGLAAEGSLSRVASIQSEPGQQ
    NLLVQQPLGRKRGLRQLRRPLLSRQKTQTEPRNRQGARLSTTRRSIQPKT
    KPSADQKRSVTFIEAQPEPAAAPTDALPATGQLQGCSPAPSRKPEAMDEP
    VLTSSPAIVVADLHSVSPKQSENFPTEEGEKEEDTEAQGATAHSPLSAQL
    SDPDDFTGLETSSLLQHGDTVLHISEENGMENPLLSSQFTFTPTELGKTD
    AVLDESHV

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements

Target

  • Target Protein
  • UNC80
  • Full Name
  • Unc-80 homolog, NALCN channel complex subunit
  • Introduction
  • The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues.
  • Alternative Names
  • UNC80; UNC-80; C2orf21; protein unc-80 homolog; unc-80 homolog, NALCN activator; KIAA1843; Unc-80 homolog, NALCN channel complex subunit

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