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Magic™ Membrane Protein Human VDAC1 (Voltage dependent anion channel 1) (CAT#: MP0035F)

Datasheet
VDAC (Voltage-Dependent Anion Channel) is a mitochondrial porin located in the outer mitochondrial membrane (OMM). This protein consists of a transmembrane β-barrel with an N-terminal α-helix. VDAC is responsible for the exchange of adenine nucleotides, Ca2+ and other metabolites across the mitochondrial membrane, it also has binding sites for glycerol, hexokinase II, creatine kinase and Bcl-2 family members. VDAC plays a central role in the increase of mitochondrial membrane permeability as part of apoptosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • VDAC1
  • Protein Length
  • Full Length
  • Protein Class
  • Channel
  • Molecular Weight
  • 30.7 kDa
  • Sequence
  • MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLET
    KYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKR
    EHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQL
    HTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNS
    SLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA

Product Description

  • Activity
  • Validated
  • Application
  • Screening & display technologies, Structural biology
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >75% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • VDAC1
  • Full Name
  • Voltage dependent anion channel 1
  • Introduction
  • This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.
  • Alternative Names
  • PORIN, VDAC-1

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