Magic™ Membrane Protein Mouse Kcna3 (Potassium voltage-gated channel, shaker-related subfamily, member 3) (CAT#: MP0022F)

Datasheet

Kv1.3 is a voltage-gated potassium channel that participates in cellular processes such as neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, apoptosis, cell volume regulation, and T cell stimulation. Kv1.3 channels have been proposed to be crucial in the pathogenesis of multiple sclerosis and other autoimmune diseases Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Product Specifications

Host Species
Mouse

Target Protein
Kcna3

Protein Length
Full Length

Protein Class
Channel

Molecular Weight
58 kDa

Sequence
MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVV
INISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGG
RIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYP
ESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSG
ASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTEL
AERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFI
GVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIA
GVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKS
EYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

Product Description

Activity
Validated by Patch clamp

Application
Screening & display technologies, Antibody development, Structural biology

Expression Systems
Cell-free expression system in the presence of lipid vesicles

Tag
Histidine tag fused to the N-terminal end of the protein

Protein Format
Proteoliposome

Purification
Sucrose gradient

Purity
>60% by SDS-Page and Coomassie Blue staining

Buffer
Tris 50mM, pH 7.5

Target

Target Protein
Kcna3

Full Name
Potassium voltage-gated channel, shaker-related subfamily, member 3

Introduction
Kcna3 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Alternative Names
Mk-3, Kv1.3, Kca1-3

Gene ID
16491

UniProt ID
P16390

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