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Magic™ Membrane Protein Rat Kcna2 (Potassium voltage-gated channel subfamily A member 2) (CAT#: MP0021F)

Datasheet
Kv1.2 is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Can form functional homotetrameric channels and heterotetrameric channels (with KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well). Channel properties depend on the type of alpha subunits that are part of the channel. Roles include pacemaking and preventing hyper-excitability and aberrant action potential firing at a presynaptic level.

Product Specifications

  • Host Species
  • Rat
  • Target Protein
  • Kcna2
  • Protein Length
  • Full Length
  • Protein Class
  • Channel
  • Molecular Weight
  • 57 kDa
  • TMD
  • 6
  • Sequence
  • MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG
    DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE
    EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF
    CLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR
    FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR
    VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPS
    IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE
    TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA
    NCTLANTNYVNITKMLTDV

Product Description

  • Activity
  • To be tested
  • Application
  • Screening & display technologies, Structural biology
  • Expression Systems
  • Cell-free expression system in the presence of lipid vesicles
  • Tag
  • Histidine tag fused to the N-terminal end of the protein
  • Protein Format
  • Proteoliposome
  • Purification
  • Sucrose gradient
  • Purity
  • >60% by SDS-Page and Coomassie Blue staining
  • Buffer
  • Tris 50mM, pH 7.5

Target

  • Target Protein
  • Kcna2
  • Full Name
  • Potassium voltage-gated channel subfamily A member 2
  • Introduction
  • KCNA2 encodes the Kv1.2 potassium channel, a delayed rectifier class of potassium channel that enables neuronal repolarization after an action potential. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
  • Alternative Names
  • BK2, NGK1, Kv1.2

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