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Magic™ mPro Human HCRTR1 Cell Line (CAT#: S01YF-1122-KX44)

Datasheet
This product is a stable cell line. It stably expresses Human HCRTR1 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • HCRTR1
  • Target Protein Species
  • Human
  • Target Classification
  • GPCR
  • Target Family
  • Orexin Receptors
  • Target Research Area
  • CNS Research
  • Related Diseases
  • Narcolepsy; Rohhad

Product Properties

  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Hypocretin receptor 1
  • Introduction
  • The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B.
  • GPCR Signaling Pathway
  • The endogenous ligand is orexin. Targeted protein activation can cause binding of Gq to G11 protein which, in turn, activate a phosphatidylinositol-calcium second messenger system.
  • Endogenous Ligand
  • Orexin
  • Alternative Names
  • OX1R; orexin receptor type 1; hypocretin (orexin) receptor 1; hypocretin receptor type 1; orexin receptor 1; HCRTR1; Hypocretin receptor 1

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