Close

Magic™ mPro Human KCNQ2/KCNQ4 Cell Line (CAT#: S01YF-1122-KX108)

This product is a stable cell line. It stably expresses Human KCNQ2/KCNQ4 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • KCNQ2/KCNQ4
  • Target Protein Species
  • Human
  • Target Classification
  • Ion Channel
  • Target Family
  • Voltage Gated Potassium Channel
  • Target Research Area
  • Auditory and Otology Research; CNS Research
  • Related Diseases
  • Developmental And Epileptic Encephalopathy; Seizures, Benign Familial Neonatal; Benign Familial Neonatal Epilepsy

Product Properties

  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Potassium voltage-gated channel subfamily Q member 2
  • Introduction
  • The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
  • Alternative Names
  • EBN; BFNC; DEE7; EBN1; ENB1; HNSPC; KV7.2; KCNA11; potassium voltage-gated channel subfamily KQT member 2; neuroblastoma-specific potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; voltage-gated potassium channel subunit Kv7.2; KCNQ2; Potassium voltage-gated channel subfamily Q member 2

Customer reviews and Q&As    

Related Products
Online Inquiry
CONTACT US
USA:
Europe:
Germany:
Call us at:
USA:
UK:
Germany:
Fax:
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2025 Creative Biolabs. | Contact Us