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Magic™ mPro Human SSTR4 Cell Line (CAT#: S01YF-1122-KX55)

This product is a stable cell line. It stably expresses Human SSTR4 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • SSTR4
  • Target Protein Species
  • Human
  • Target Classification
  • GPCR
  • Target Family
  • Somatostatin Receptors
  • Target Research Area
  • Cancer Research; CNS Research
  • Related Diseases
  • Prolactinoma; Hormone Producing Pituitary Cancer

Product Properties

  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Somatostatin receptor 4
  • Introduction
  • Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.
  • GPCR Signaling Pathway
  • The endogenous ligand is somatostatin. Targeted protein activation can cause binding of Gi to Go protein which, in turn, cause an inhibition of adenylate cyclase and then decrease of cAMP concentration.
  • Endogenous Ligand
  • Somatostatin
  • Alternative Names
  • SS4R; SS4-R; SS-4-R; somatostatin receptor type 4; G-protein coupled receptor; SSTR4; Somatostatin receptor 4

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