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Magic™ mPro Rat CHRM4 Cell Line (CAT#: S01YF-1122-KX64)

Datasheet
This product is a stable cell line. It stably expresses Rat CHRM4 to provide cell models for research and screening applications.

Product Information

  • Target Protein
  • CHRM4
  • Target Protein Species
  • Rat
  • Target Classification
  • GPCR
  • Target Family
  • Acetylcholine Receptors
  • Target Research Area
  • CNS Research; Digestive and Renal Research
  • Related Diseases
  • Ureterolithiasis

Product Properties

  • Mycoplasma Testing
  • Negative
  • Biosafety Level
  • Level 1
  • Activity
  • Yes
  • Form
  • Frozen cells
  • Selective Antibiotic(s)
  • Regular antibiotics active against mycoplasmas, bacteria and fungi.
  • Handling Notes
  • Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
    Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
    Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
  • Incubation
  • 37°C with 5% CO₂
  • Applications
  • Drug screening and biological assays
  • Application Notes
  • Cells were plated in a 384-well plate and incubated overnight at 37°C and 5% CO₂ to allow the cells to attach and grow. Cells were then stimulated with a control for high-throughput drugs screening andfunctional assays.
  • Use Restrictions
  • These cells are distributed for research use only.
  • Shipping
  • Dry ice
  • Storage
  • Liquid nitrogen

Target

  • Full Name
  • Cholinergic receptor, muscarinic 4
  • Introduction
  • Enables guanyl-nucleotide exchange factor activity. Involved in response to organic substance. Located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Colocalizes with sarcolemma. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4).
  • GPCR Signaling Pathway
  • The endogenous ligand is acetylcholine. Targeted protein activation can cause binding of Gi to Go protein which, in turn, cause an inhibition of adenylate cyclase and then decrease of cAMP concentration.
  • Endogenous Ligand
  • Acetylcholine
  • Alternative Names
  • M4; muscarinic acetylcholine receptor M4; cholinergic receptor, muscarin 4

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