Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsThe Mas-related G protein-coupled receptors (MRGPRs) comprise a subfamily of GPCRs. MRGPRs family comprises almost 40 members which can be grouped into nine distinct subfamilies (MRGPRA to -H and -X) and almost all the members are still considered "orphan" with no endogenous ligands identified. However, several distinct peptides and amino acids are evaluated as potential ligands, including β-alanine, angiotensin-(1-7), alamandine, GABA, cortistatin-14, and cleavage products of proenkephalin, pro-opiomelanocortin, prodynorphin, or pro-neuropeptide-FF-A.
Most MRGPRs, including all MRGPRA, MRGPRB, and part of MRGPRC and MRGPRD subfamily members, are nearly and exclusively expressed in specific dorsal root and trigeminal ganglia neurons and play important roles in nociception, itch, or pruritus, and thermosensation. Some MRGPRs, such as human MRGPRX2 and rat MRGPRB3, are probably the long-sought low-affinity, low-selectivity receptors on mast cells that mediate IgE-independent degranulating actions. In vitro overexpression cells, MRGPRs present tumorigenic and proliferative actions when the accumulation exceeds a certain threshold, which is normally not reached in vivo. Some MRGPRs have been shown to be expressed in cardiovascular organs and exploited its protective actions in cardiovascular and metabolic diseases. The further investigations on MRGPRs reveal their physiologic and pathophysiologic functions with great therapeutic potency.
Here shows a part of members of MRGPRs, including MRGPRD to -G and MRGPRX1 to -X4. MRGPRD is the first identified non-orphan receptor that recognizes β-alanine as a ligand and its activation is transmitted by both Gq and Gi proteins onto changes of intracellular Ca2+ and cAMP. MRGPRE most likely binds MRGPRD to form heterodimers. MRGPRX1 can be activated by BAM22, a product of proenkephalin A metabolism. β-defensins (e.g., hBD2 and hBD3) and cathelicidines (e.g., LL-37), are ligands for MRGPRX2 receptor on human mast cells. For MRGPRF, MRGPRG, MRGPRX3 and MRGPRX4, no ligand has been described yet.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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